Southeast Alaska economy: ‘Every year from now on, we’re going to be comparing it to 2020’

first_imgCommunity | Coronavirus | Economy | Juneau | SoutheastSoutheast Alaska economy: ‘Every year from now on, we’re going to be comparing it to 2020’August 14, 2020 by Elizabeth Jenkins, KTOO Share:The Franklin Food Court in downtown Juneau. (Photo by Elizabeth Jenkins/KTOO)A new report captures a grim economic snapshot of how COVID-19 has affected Southeast Alaska. Not surprisingly, businesses that get a major boost from tourism have been hit the hardest. And while the findings look pretty bleak, it could serve as a roadmap for where to go next. Audio Playerhttps://media.ktoo.org/2020/08/14SECON.mp300:0000:0000:00Use Up/Down Arrow keys to increase or decrease volume.Franklin Food Court in downtown Juneau is the kind of spot that normally draws in tourists and locals. You can sit outside and look up at a view of the mountain peeking through tall buildings while ordering something distinctly from Alaska — salmon ice cream or halibut tacos. Today, seats in the outdoor food court are mostly empty. David McCasland is the owner of Deckhand Dave’s Fish Tacos. He says there were many unknowns leading up to the season. “Coming March time, I was like, well, we’re going to see how this goes,” he said.But so far, McCasland says his business is holding up. He opened up a little later than normal, and he was able to get a loan from the federal Paycheck Protection Program, which is helping him ride out the summer. McCasland emphatically states that he’s one of the fortunate businesses. He feels empathy for his downtown neighbors who don’t have the outdoor space to spread out and make guests feel more secure. McCasland says he’s approaching the future with a mixture of hope and caution. “It seems like this is going to continue on a little bit longer, and who knows what next summer will bring,” he said.According to information collected for an economic report commissioned by Southeast Conference, 17% of Juneau businesses said they were at risk of closing over the next 12 months. That sounds bad. But across the region, that number is even higher: 23%. Meilani Schijvens from Rain Coast Data helped put the economic report together using surveys of 460 businesses across the region. “I tell people that this report is really heavy,” she said. “It’s really hard. It’s really depressing.”Schijvens says places like Petersburg were more insulated from the economic downfall because the community isn’t as dependent on cruise ship tourism. Haines and Skagway, on the other hand, have been feeling that revenue loss the most. “You have COVID, and you take those cruise ships away. And the elements that the economy has been built on are destabilized,” Schijvens said.As of June, fewer businesses in Southeast Alaska reported receiving federal COVID relief funds compared to distributions across the state. Schijvens isn’t sure why that is. But she thinks the $52 million dollars of funding businesses did receive was extremely helpful. Schijvens says this report didn’t show a lot of bright spots, but she thinks the region still has a lot going for it. Southeast Alaska is a place tourists will want to visit again — someday. She says this report reads as a kind of manual for how to best support businesses at this time. Most businesses named access to grants and utility assistance as the top two things that could help get them through this year.“Every year from now on, we’re going to be comparing it to 2020,” Schijvens said. “And it’s going to be improving, so we’re going to be able to look back at 2020, and say, ‘we’re doing so much better than 2020. So this is our bottom year.’”Share this story:last_img read more

First he pioneered a new way of making life. Now he wants to try it in people

first_img PORTLAND, Ore. — The next great advance in fertility treatments may rest with five young monkeys in a lab outside of town.Each of the five carries genes from three parents instead of two, because they were conceived using a novel — and controversial — gene therapy. They seem to be completely ordinary. But researchers are watching them closely to make sure they age normally, can reproduce, and have healthy children.If so, the three-parent fertilization technique will likely be tried in humans, potentially helping women with certain genetic glitches give birth to healthy children. The same approach might also someday provide older women a chance to extend their fertility by freshening up their eggs with contributions from another woman.advertisement Leave this field empty if you’re human: Serious mutations in these 37 mitochondrial genes doom a fetus; slightly milder mutations can lead to muscle weaknesses, heart problems, and intellectual disabilities. Symptoms can turn up at birth or later in life. It isn’t possible to identify a mitochondrial disease in an embryo, so most women who know they are carriers of mitochondrial mutations decide not to have biological children.Hoping to offer them a chance to have genetically related children, Mitalipov has pioneered a method dubbed “three-parent embryos.”Step one: He takes the nucleus out of the egg of the mother-to-be.Step two: He strips a donor egg of its nucleus.Step three: He implants the mother’s nucleus into the donor egg. The resulting cell now contains DNA from two women: The mother’s DNA in the nucleus (where the bulk of genetic material resides) and the donor’s DNA in the mitochondria.The egg is then fertilized in vitro, adding the man’s DNA and — if all goes well — creating an embryo.So far, Mitalipov has tried this only on mice and a handful of monkeys. He is eager to try the technique to prevent human disease.Potential patients are excited, too.“It has given many mitochondrial disease families a lot of hope,” said MaryBeth Hollinger, a New York-based nurse navigator for the advocacy group MitoAction.Of course, families want the procedure to be safe, Hollinger said, but they are willing to take some risks to avoid passing on a devastating disease to their children.‘Too many question marks’Both Mitalipov and his friendly rival in the field, Dieter Egli of the New York Stem Cell Foundation, maintain that changing an egg’s mitochondrial DNA is different from tinkering with the bulk of the genetic material in the nucleus.And Mitalipov believes his energetic young monkeys — Mito, Tracker, Spindler, Spindy, and Chrysta, all rhesus macaques — are living proof that the technique is safe. Leave this field empty if you’re human: The best way to rein in these glitches is to maximize the number of healthy mitochondria, Mitalipov said. Exercise may do that when we’re young, but probably won’t do much to reverse damage once it’s done, he said. He takes “a whole bunch of antioxidants,” hoping to improve his mitochondrial health, though he’s not sure it will make a difference.The more he learns about mitochondria, the more he’ll be able to help people live long, healthy lives, Mitalipov said.Amato, his obstetrician colleague, said Mitalipov deserves more credit for such vision than he’s gotten.“He’s a very understated kind of person,” she said. “He’s sort of a humble guy and goes about his business and doesn’t have to be the rock star. But he really is.” Related: By Karen Weintraub July 8, 2016 Reprints “You don’t want to say ‘My science will help 100 years from now.’ Maybe it will, but I want it while I’m here,” said Mitalipov, who directs the Center for Embryonic Cell and Gene Therapy at Oregon Health & Science University. Related: Tags fertilitygene editingwomen’s health Please enter a valid email address. NewslettersSign up for The Readout Your daily guide to what’s happening in biotech. In interviews at his lab in downtown Portland and his office at the Oregon National Primate Research Center — where a stuffed monkey, a gift to the lab, is one of the few personal touches — Mitalipov laid out his vision for his research and discussed the uproar it’s caused, and what makes it all worthwhile.The son of two teachers, Mitalipov was born in Kazakhstan, then part of the Soviet bloc, and went to college in Moscow. His first research lab was the only one in Moscow studying embryonic stem cells, back when the field was embryonic itself.Now, he’s one of the few researchers in the world to study a type of genetic manipulation — essentially cloning — in hopes of eventually improving human health.And he is a devotee of a genome that few others bother to explore: The mitochondria that provide energy — and their own 37 genes — to every cell in our bodies.Mitochondria are particularly fascinating, Mitalipov said, because they are meticulous timekeepers.“We came to this [mitochondrial] DNA as a genome that probably affects a lot more than we think,” he said with a thick accent and grammatical structure that still betray his Soviet upbringing. “Not only disease, not only aging. … It seems like there was a niche that no one studied … so we built a program around it.”The path to ‘three-parent embryos’In freshman biology, most of us learned that mitochondria are the “powerhouse of the cell,” floating around outside the nucleus and serving as living batteries.The iconic drawings of cells show a few ovals with squiggles inside — but in truth, a normal, healthy cell might have upward of 1,000 mitochondria, each with its own DNA. These genes are inherited only from mothers. (The vastly bigger nuclear genome, of 20,000 genes, is a relatively even mix from mother and father.) Privacy Policy In the LabFirst he pioneered a new way of making life. Now he wants to try it in people Related: Please enter a valid email address.center_img @kweintraub FDA urged to approve ‘three-parent embryos,’ a new frontier in reproduction “So far, nothing,” Mitalipov said.Research in mice suggests there could be some reason for concern.A study published last month in Cell Stem Cell found that even if 99 percent of a mother’s flawed mitochondria were removed through mitochondrial replacement, the remaining 1 percent could still be passed down to future generations and expand to essentially take over the mitochondrial genes.Another study out this week in Nature shows that mice whose nuclear and mitochondrial DNA come from different mothers — in other words, those with three genetic parents — age faster than normal mice, “resulting in profound differences in health longevity.”The studies don’t concern Mitalipov. He focuses on the successes.But he struggles to keep his cutting-edge work funded; he’s entering an American research competition, hoping to win enough money to eventually breed Chrysta and study the third generation of offspring. He jokes about bringing pictures of irresistibly cute monkey babies to convince the judges.He’s also keeping a wary eye on congressional debate about whether to allow mitochondrial replacements in humans.“We’d like to be the first people to do it, since we were the first people to do it in [monkeys],” said Dr. Paula Amato, a fertility specialist and obstetrician at OHSU who collaborates with Mitalipov.There’s simply no way to eliminate all the risks before trying the technique in people, she said.“We’ve done everything we can to show that it likely would be safe, but ultimately you never know until you do it,” Amato said.A humble rock starMitalipov remains fascinated by the area of a woman’s egg cell that falls outside the nucleus. It’s filled with mitochondria, fluid, and the secret ingredients of humanity.“It’s a woman’s egg cytoplasm that gives life, not its nucleus,” he said. Scientists still don’t know what makes a good or bad egg, but it’s clear that “with aging, something goes wrong with cytoplasm activity.”That’s why older women are less fertile than younger ones. “Women in their 40s, their eggs, no matter what you do, doesn’t seem like they’re producing a viable embryo,” he said.But an older woman can successfully carry a pregnancy from a younger woman’s egg. “So everybody knows it’s an egg problem, but people don’t realize which part of the egg is the problem,” he said. “In my lab, we think it is the maturation of the cytoplasm that is the major issue.”The mitochondria we get from this cytoplasm may also determine how long we live.Mitalipov believes his rising blood pressure has something to do with the aging of his mitochondria. After about age 50, mitochondrial mutations rise; after 70, they go through the roof. Mice that are bred to have lots of these genetic errors die substantially sooner than normal mice. Karen Weintraub is an independenthealth/sciencejournalist, journalism teacher, and bookauthor. Such genetic manipulation sounds uncomfortably like “playing God” to some critics. But the scientist behind the fuzzy-haired monkeys pushes on, as he always has, in a career spent on the scientific frontier.At age 54, Shoukhrat Mitalipov has a wrestler’s build and jet-black hair that stands up in spikes. He also has a fierce desire to get results in the here and now.advertisement The UK government approved use of the three-parent technique in humans last year, though no research group has yet done it. In the United States, however, Congress is contemplating banning the approach, known as mitochondrial replacement therapy.And some scientists worry it’s too soon for human trials.“If someone were to proceed with it now, my own view is that’s probably irresponsible. There are so many question marks. I just think it’s premature,” said Paul Knoepfler, a stem cell biologist at the University of California, Davis.At minimum, Knoepfler said, the offspring of these “three-parent” families should be limited to males, so they can’t pass on their mitochondria to the next generation.Despite his hesitations, Knoepfler said he doesn’t doubt that Mitalipov’s heart is in the right place, and praised him for continuing the research.“I appreciate the fact that he’s willing to tackle some really tough things,” Knoepfler said. “He’s been willing to take risks, to really push and invest time and energy into this cool stuff that almost nobody else has been even trying to do until just recently.”Other peers of Mitalipov also respect his work, calling him a serious scientist who isn’t afraid of controversy, but also isn’t out to feed his own ego. They uniformly refer to him as “nice,” though none said they knew him well enough to describe him further.For his part, Mitalipov said he has no real hobbies outside of work and his family. He used to play blues guitar, but now is excited to listen to his favorite music on Pandora. His teenagers showed him how to work the app so he can listen to Stevie Ray Vaughn during his commute.“I cannot keep up with all this technology,” he said.A delicate touch on egg cell surgeryIt takes a very delicate hand to do intricate surgery on egg cells, and in Mitalipov’s lab, only he and one other researcher can do it. He said his eyes are not as good as they used to be, so his colleague recently came in to do research on a freshly donated human egg — just a week after giving birth to her own baby.Mitalipov learned the techniques in Moscow and then honed them as a young PhD student at Utah State University.His first project was aimed at understanding why embryonic stem cells are essentially immortal. “The female germline doesn’t have a clock — it’s always zero,” he said. “That’s why when we get mitochondria from our mother, it’s set at zero, not her age.”An early mentor was Keith Campbell, then in the process of cloning Dolly the sheep — born 20 years ago this week. The young Mitalipov, who still had just a rudimentary command of English, met Campbell at a conference in Utah, and was enthralled. The senior scientist was generous with his time and his tips, and the two bonded over their common interests in science and beer.His whole career, Mitalipov said, has consisted of tinkering with the nuclear transfer techniques that Campbell, who died a few years ago, developed in the mid-90s.“My clinical goal was to use some of the basic knowledge to improve human reproduction,” Mitalipov said. “The IVF platform can be used now to remanufacture gametes, to treat infertility, but also as a platform for gene therapy, which is probably where the future will go.”Spindler and Spindy, two of the monkeys created from the DNA of three parents. Oregon Health & Science UniversityRed flags from recent studiesMito, Tracker, Spindler, and Spindy are now 7; Chrysta has turned 4. Mitalipov said he’s been asked by the US Food and Drug Administration and the UK government to follow them as they age to make sure they remain normal.He also hopes to breed Chrysta to see how her offspring fare, and to study the mitochondrial DNA she passes on to them.Monkeys don’t reproduce until they’re 6 or 7 — and they live 15 to 20 years in captivity — so it will be a long wait to figure out if these animals have any health problems. Privacy Policy About the Author Reprints Shoukhrat Mitalipov Daniel Berman for STAT New advances in growing human embryos could prompt ethical firestorm Karen Weintraub Newsletters Sign up for Weekend Reads Our top picks for great reads, delivered to your inbox each weekend. Beyond three-parent babies: New drugs offer hope for mitochondrial disease last_img read more

DEO says expiration message about reapplying for unemployment is false

first_img By The Penny Hoarder It’s been an exhausting year for Florida’s unemployed, and as we begin 2021 there are new hurdles for people to jump through before they get their next check.The DEO is warning people they have just hours to file a new application or risk losing it all.The message warns people they have until midnight Saturday, January 2 to file a new application or they will lose all their benefits.The DEO said to ignore the message, and said they’re working to fix it. Florida nursing homes report COVID-19 infection rates nearly double the national average June 16, 2021 RELATEDTOPICS DEO investigates claims of hacking and stealing unemployment benefits June 15, 2021 Advertisement “I feel like I’ve been discriminated against because they called back almost everybody except some of the older ladies,” Harris said.She now joins thousands who are awaiting word from the DEO on when they’ll get their next check.Wendy DeLand is among those receiving a message that her benefits are about to expire, although she’s still owed money.The DEO said the message was a mistake and they’re working to fix it.“This has gone on this many months and they can’t get things in order,” DeLand said.The state can’t even say when the next round of federal unemployment will go out since they’re awaiting direction from the federal government.State Representative Anna Eskamani, who has become an advocate for the unemployed, predicts it’s likely to be days before the money goes out.“Our office has been flooded with very similar questions, and I do see at least a week delay,” Eskamani said.People are also being warned to ignore an email which appears to come from the DEO. It looks legitimate and tells people that because of the new round of stimulus they qualify for an additional $12,000 in benefits and all you have to do is verify your identity.The DEO said don’t do it — it’s a scam.Finally, according to the DEO website, Gov. DeSantis waived the work search requirement to look for a job until late February 27. Yup — you’ve got some algorithm spitting out a three-digit number that’s basically controlling your entire life. We… If Your Credit Score Ever Falls Under 700, Make These 5 Moves ASAPcenter_img AdvertisementDC Young Fly knocks out heckler (video) – Rolling OutRead more6 comments’Mortal Kombat’ Exceeded Expectations Says WarnerMedia ExecutiveRead more2 commentsDo You Remember Bob’s Big Boy?Read more1 commentsKISS Front Man Paul Stanley Reveals This Is The End Of KISS As A Touring Band, For RealRead more1 comments Over 1,000 unemployment claim call takers let go as DEO cancels contract June 12, 2021 Sponsored Content AdvertisementTags: DEOFloridaunemployment AdvertisementRecommended ArticlesBrie Larson Reportedly Replacing Robert Downey Jr. As The Face Of The MCURead more81 commentsGal Gadot Reportedly Being Recast As Wonder Woman For The FlashRead more29 comments AdvertisementBut the system was down again, and people can’t access it while they wait to hear when the new unemployment money will go out.“If we get anything I’ll figure it was a blessing,” said Paulette Harris.Harris lost her job last spring, and so far, said she has not been called back. Two suffer shark bites off Florida beach June 16, 2021last_img read more

Higher household debt leads to longer recessions, IMF says

Economies with hefty household debt loads tend to suffer longer, deeper, recessions says new research from the International Monetary Fund. In a new report, the IMF says its analysis of advanced economies over the past 30 years finds that housing busts and recessions that are preceded by larger run-ups in household debt “tend to be more severe and protracted”, due to the combination of dropping house prices and the large resulting debt overhang. Income inequality narrowed amid fiscal supports in 2020: StatsCan Keywords Consumer borrowing and saving,  MortgagesCompanies International Monetary Fund Facebook LinkedIn Twitter Related news James Langton “Household consumption and real GDP fall more, unemployment rises more, household deleveraging— paying off debts or defaulting on them—is more pronounced, and the slump persists for at least five years,” it says. And, it finds the larger contractions in economic activity in the wake of such busts aren’t just due to the fall in house prices, or resulting banking crises. “Rather, it is the combination of house price declines and the prebust run-up in leverage that explains the severity of the contraction,” it concludes. The report also finds that government policy can do a lot to minimize these effects. While macroeconomic policies — such as unemployment insurance, monetary easing, and bank bailouts — are crucial in preventing excessive contractions in economic activity, these sorts of policies have their limits. Interest rates can only go so low, and government debt can limit fiscal transfers. However, the IMF says that it has found that targeted household debt restructuring policies can deliver significant benefits. “Bold and comprehensive programs, such as those implemented in the United States in the 1930s and in Iceland today, can significantly reduce the number of household defaults and foreclosures and substantially reduce debt repayment burdens, at a relatively low fiscal cost,” it says. By enacting policies to reduce defaults and foreclosures, governments can prevent self-reinforcing cycles of declining house prices and lower aggregate demand, it says. However, it also stresses that the success of such programs depends on their design. Overly restrictive policies can limit the programs’ effectiveness, whereas programs that are to broad can undermine the health of the financial sector. Share this article and your comments with peers on social media Consumer debt driven by new mortgages, but credit card debt at six-year low Tougher stress tests won’t chill housing market: Scotia read more

Ampol State of Origin returns to Adelaide

first_imgAmpol State of Origin returns to Adelaide South Australian Tourism CommissionSouth Australia will again welcome the biggest rivalry in Rugby with the return of the Ampol State of Origin in 2023.The National Rugby League, in conjunction with the South Australian Government and the South Australian Tourism Commission, today announced that Adelaide Oval would host a match in the 2023 series, following the success of the first NRL match at the iconic venue last year.Premier Steven Marshall said South Australia has secured the rights to host the 2023 event at Adelaide Oval – the neutral venue in the three game series.“It’s a great result for rugby fans, but also a big win for South Australian hotels, restaurants and cafes,” Premier Marshall said.“More than 20,000 interstate visitors are expected to visit Adelaide to help celebrate the big match – injecting an estimated $15 million into the South Australian economy.“Last year’s NRL State of Origin game was a real hit and delivered a cracking game in front of more than 25,000 fans – including 4,000 from interstate,” Premier Marshall said.“Events like these create jobs and vibrancy in our great city and it’s fantastic to be able to welcome interstate Blues and Maroons fans back to Adelaide.”Australian Rugby League Commissioner Peter Beattie AM, in Adelaide for the announcement along with NSW rugby legend Robbie Farah, thanked the South Australian Government and the South Australian Tourism Commission for their support of rugby league and embracing Origin in 2020.“We want to build on what we started last year,” Mr Beattie said.“The Adelaide Oval match was a great success. We had a capacity COVID crowd and the way the city embraced the Origin Series gives us every confidence of filling the venue in 2023. State of Origin is the most successful sporting brand in Australia which we now play in the five biggest capital cities in Australia.”Queensland Maroons Coach Paul Green said: “From all reports, our players and fans really enjoyed last year’s Origin experience in Adelaide.“It was obviously a great night for our supporters and the players and coaches who played their part in a memorable win.“It’s always exciting to showcase State of Origin in new markets and at iconic sporting venues like the Adelaide Oval, so I’m sure there will be a lot of people looking forward to this game in 2023.” /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:Adelaide, Australia, Australian, Australian Government, Commission, Commissioner, Economy, Government, league, National Rugby League, NSW, Premier, Queensland, Rugby, SA, South Australia, tourismlast_img read more

Temporary Closure in Lithgow Local Government Area

first_imgTemporary Closure in Lithgow Local Government Area Lithgow CouncilCouncil wishes to update residents of the temporary closure of the following roads in the LGA.Geordie Street Causeway Crossing, LithgowTarana/Sodwalls, Tarana – Between top of Magpie Hollow Road and Jerrys Meadow Road.Marsden Swamp Road CausewayGanbenang Road CausewayThese road closures have been put in place for safety of the residents due to flooding over the roads and causeways.The patience of affected residents is appreciated and Council advises that changed traffic conditions must be observed by all motorists travelling through the area. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:council, Government, Lithgow, local council, Local Government, road closure, Safety, Taranalast_img read more

VUMC to lead national study to treat severe COVID complications

first_imgVUMC to lead national study to treat severe COVID complications by Bill SnyderThe Vanderbilt Institute for Clinical and Translational Research (VICTR) has been awarded a major federal grant to lead a national trial of treatments targeting the Renin Angiotensin Aldosterone System (RAAS) in patients hospitalized with COVID-19.Comprised of the hormones renin, angiotensin and aldosterone, RAAS is essential for the regulation of blood pressure and fluid balance. SARS-CoV-2, the virus that causes COVID-19, can disrupt this system, resulting in life-threatening complications, including pulmonary edema, thromboembolic complications and severe cardiac injury.Sean Collins, MD, MSc, professor of Emergency Medicine at Vanderbilt University Medical Center, who has deep expertise in emergency care and RAAS, will lead the trial, which will test whether drugs targeting RAAS can prevent the vascular, fibrotic and inflammatory consequences of severe COVID-19 disease.The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), will provide up to $60 million through the grant, which will be distributed through administrative partners at RTI International, an independent nonprofit research institute based in Research Triangle, North Carolina.The national trial, called ACTIV-4d, is part of Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV), a public-private partnership coordinated by the Foundation for the National Institutes of Health. ACTIV unites partners from government, industry, academic and nonprofit organizations to prioritize and speed development of the most promising COVID-19 treatments.The ACTIV-4d RAAS trial will enroll approximately 1,600 patients at more than 50 sites, including members of the NHLBI-supported Prevention and Early Treatment of Acute Lung Injury (PETAL) Network.VICTR and the Vanderbilt Coordinating Center (VCC), which Collins co-directs and which provides support for clinical trials at VUMC, will jointly oversee the ACTIV-4d RAAS trial in the role of clinical and data coordinating center.“While RAAS is central to both the mechanism of viral entry and the multiple organ dysfunctions associated with COVID-19, RAAS-targeted therapies remain understudied,” Collins said. “The ACTIV-4d RAAS platform has tremendous potential to clarify the impact of restoring RAAS balance in patients hospitalized with COVID-19 and to identify a therapy for patients affected by the disease.”The SARS-CoV-2 spike protein binds the receptor for angiotensin-converting enzyme 2 (ACE2) on cell surfaces in the body, enabling the virus to enter cells and hijack their genetic machinery to replicate itself. Binding ACE2 also prevents the processing of angiotensin II (Ang II), thus creating RAAS imbalance.ACTIV-4d will test multiple agents acting through separate mechanisms to determine if restoring RAAS balance in patients with COVID-19 improves clinical outcomes. The platform is expected to include at least three investigational drugs:TXA127, an investigational agent from Constant Therapeutics LLC, is a pharmaceutical formulation of the natural human peptide Ang 1-7, which binds the Mas receptor. It triggers physiological functions that oppose the vascular, immune and fibrotic effects of Ang II through the Ang II-type 1 receptor (AT1R).TRV027, an investigational drug from Trevena Inc., is a small molecule selective agonist for AT1R, which induces beneficial signaling through the beta-arrestin signaling pathway in a way that improves vascular, immune and fibrotic responses.APN01, an investigational drug from APEIRON Biologics, is a circulating recombinant version of the human ACE2 receptor. APN01 binds the SARS-CoV-2 spike protein, thereby preventing the virus from attaching to ACE2 on cell surfaces. This diversion prevents viral entry and allows cellular ACE2 to convert circulating Ang II to Ang 1-7.“We are very hopeful that NHLBI’s platform of trials will help advance the understanding of COVID-19 and treatment options for severely ill patients with the disease,” said Wesley Self, MD, MPH, who leads the ACTIV-4d RAAS Clinical Coordinating Center at VUMC.Self, who has extensive COVID-19 and other clinical trial experience at VUMC and in PETAL, is associate professor and vice chair for Research in the Department of Emergency Medicine and VICTR’s vice president for Clinical Research Networks & Strategy.Matt Shotwell, PhD, associate professor of Biostatistics, will lead the VUMC Data Coordinating Center for ACTIV-4d RAAS. Experienced in data management, statistical methodology and adaptive clinical trial design, Shotwell is a member of the VICTR Research Methods Program.Headed by Gordon Bernard, MD, the Melinda Bass Owen Professor of Medicine and Executive Vice President for Research at VUMC, VICTR is supported by a Clinical and Translational Science Award (CTSA) as well as other federal funding.Since June 2020 VICTR has served as the Science Unit for CONNECTS /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:Bass, clinical trials, emergency care, emergency medicine, gordon, Government, health, North Carolina, Owen, President, prevention, regulation, therapeutics, university, Vanderbilt University, VIClast_img read more

COP26 President-Designate Alok Sharma visits summit partner Italy

first_imgCOP26 President-Designate Alok Sharma visits summit partner Italy Mr Sharma to meet Italian President and ministersItaly is the UK’s partner for hosting crucial COP26 climate summitVisit marks the next step on the President-Designate’s work with countries to make COP26 a successMr Sharma is expected to meet senior government figures including the President of the Senate Maria Casellati and Ecological Transition Minister, Roberto Cingolani, as well as young climate activists and international organisations such as the International Fund For Agricultural Development.During his visit, Mr Sharma will underline how important the UK and Italy’s close relationship is, as we work as partners to make COP26 and our G7 and G20 Presidencies a success for climate action.The President-Designate has been travelling extensively ahead of the summit in Glasgow this November. He has been taking the Presidency’s four goals for COP26 across the world: limit warming to 1.5 degrees, adapting to protect communities and natural habitats, mobilising climate finance and working together to accelerate action.In Italy he will make it especially clear how vital it is to support countries vulnerable to the impacts of climate change. This means making progress towards reaching the annual commitment developed countries made to raise $100bn in climate finance each year.Ahead of the trip, COP26 President-Designate Alok Sharma said:“I am immensely grateful to our COP26 partners Italy for the close relationship we have built together as we work towards a successful outcome from the summit in Glasgow this November.“Both our countries recognise how urgently the world needs to act if we are to keep the chance of warming to 1.5C alive and protect our planet and people from the intensifying impacts of climate change.“As hosts of the G7 and G20 respectively, the UK and Italy have a unique opportunity to demonstrate global climate leadership this year, and I look forward to meeting a range of ministers, organisations and climate negotiators.”Notes:The COP26 President Designate will be in Rome from Monday 10 May to Tuesday 11 MayOther recent travel includes Denmark, Japan and the Vatican City. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:climate change, climate summit, Denmark, G20, G7, Government, Italy, Japan, leadership, presidency, President, Rome, the Summit, UK, UK Government, Vatican Citylast_img read more

Mercedes-Benz jumps into the pickup world with X-Class concept

first_img Excited? The X-Class will go into production sometime in 2017, but only for Europe, South America and South Africa. Unless Mercedes-Benz changes their mind, North America is out of luck.Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class concept COMMENTSSHARE YOUR THOUGHTS Mercedes-Benz has finally unveiled its highly anticipated, if not slightly polarizing, X-Class pickup truck.Technically still a concept – albeit a thinly disguised one – the X-Class shares its body-on-frame chassis with the Nissan NP300 Navara and Renault Alaskan, two pickups available outside of North America.Despite its seemingly plebeian underpinnings, the X-Class is all-Mercedes in nearly every other aspect. Mercedes has pieced together two variants of the X-Class concept; the first is a tough-looking, off-road variant which actually looks quite cool with its winch, knobby off-road tires and exposed fire extinguisher inside. But if those aren’t your thing, there’s also a more luxurious variant more befitting of the three-pointed star. Trending Videos We encourage all readers to share their views on our articles using Facebook commenting Visit our FAQ page for more information. RELATED TAGSMercedes-BenzNewsAlaskaEuropeMercedes-Benz International Inc.Nissan Motor Co. Ltd.North AmericaRenault SASouth AfricaSouth AmericaUnited States ‹ Previous Next › Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Created with Raphaël 2.1.2Created with Raphaël 2.1.2Mercedes-Benz X-Class conceptHandout, Mercedes-Benz Buy It! Princess Diana’s humble little 1981 Ford Escort is up for auction An engagement gift from Prince Charles, the car is being sold by a Princess Di “superfan” Full technical details are still under wraps, but expect to see a turbodiesel V6 as the flagship engine, along with a full-time four-wheel-drive system and a live rear axle with a coil-spring setup for a more comfortable on-road ride. Mercedes also promises a 2,200-pound payload and a tow rating of up to 7,000 pounds. The Rolls-Royce Boat Tail may be the most expensive new car ever Trending in Canada PlayThe Rolls-Royce Boat Tail may be the most expensive new car everPlay3 common new car problems (and how to prevent them) | Maintenance Advice | Driving.caPlayFinal 5 Minivan Contenders | Driving.caPlay2021 Volvo XC90 Recharge | Ministry of Interior Affairs | Driving.caPlayThe 2022 Ford F-150 Lightning is a new take on Canada’s fave truck | Driving.caPlayBuying a used Toyota Tundra? Check these 5 things first | Used Truck Advice | Driving.caPlayCanada’s most efficient trucks in 2021 | Driving.caPlay3 ways to make night driving safer and more comfortable | Advice | Driving.caPlayDriving into the Future: Sustainability and Innovation in tomorrow’s cars | Driving.ca virtual panelPlayThese spy shots get us an early glimpse of some future models | Driving.ca See More Videos advertisementlast_img read more

Audi ends its Le Mans program, jumps to Formula E

first_img See More Videos Audi today announced it is ending its wildly successful endurance racing program in the World Endurance Championship (WEC) and American Le Mans Series (ALMS) to instead focus on the new all-electric Formula E racing series.“We’re going to contest the race for the future on electric power,” said Rupert Stadler, Audi’s chairman of the board of management, in a statement. “As our production cars are becoming increasingly electric, our motorsport cars, as Audi’s technological spearheads, have to even more so.” In its 18-year involvement with prototype endurance racing, Audi has won the 24 Hours of Le Mans 13 times, two WEC championships, nine ALMS championships and 106 races overall, and has been using diesel-powered racers since 2006; it finished third at this year’s Le Mans with a diesel-hybrid LMP1 prototype. But the Volkswagen Group’s recent Dieselgate emissions scandal has shifted the company’s focus from diesel engines to electric vehicles, so Audi’s switch was inevitable.  Trending Videos For the current 2016/17 season, the German carmaker is teamed with Team ABT Schaeffler Audi Sport as a technical partner, but has plans for a full factory team in the near future. The brand will continue to field a German DTM touring car team.  COMMENTSSHARE YOUR THOUGHTS advertisement The Rolls-Royce Boat Tail may be the most expensive new car ever RELATED TAGSAudiNews24 Hours of Le MansAudi AGLe MansMotorsportsSportsVolkswagen AGcenter_img We encourage all readers to share their views on our articles using Facebook commenting Visit our FAQ page for more information. Buy It! Princess Diana’s humble little 1981 Ford Escort is up for auction An engagement gift from Prince Charles, the car is being sold by a Princess Di “superfan” Created with Raphaël 2.1.2Created with Raphaël 2.1.2 France’s Benoit Treluyer driving his Audi R18 Hybrid during the 84th Le Mans 24-hours endurance race on June 18, 2016 in Le Mans, western France. Trending in Canada PlayThe Rolls-Royce Boat Tail may be the most expensive new car everPlay3 common new car problems (and how to prevent them) | Maintenance Advice | Driving.caPlayFinal 5 Minivan Contenders | Driving.caPlay2021 Volvo XC90 Recharge | Ministry of Interior Affairs | Driving.caPlayThe 2022 Ford F-150 Lightning is a new take on Canada’s fave truck | Driving.caPlayBuying a used Toyota Tundra? Check these 5 things first | Used Truck Advice | Driving.caPlayCanada’s most efficient trucks in 2021 | Driving.caPlay3 ways to make night driving safer and more comfortable | Advice | Driving.caPlayDriving into the Future: Sustainability and Innovation in tomorrow’s cars | Driving.ca virtual panelPlayThese spy shots get us an early glimpse of some future models | Driving.ca ‹ Previous Next ›last_img read more